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Drug Name: Volasertib trihydrochloride [USAN] View Structure
Description: A polo-like kinase inhibitor with broad antitumor activity.

NCI: A dihydropteridinone Polo-like kinase 1 (Plk1) inhibitor with potential antineoplastic activity. Volasertib selectively inhibits Plk1, inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner. (NCI Thesaurus) 



 
 
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Last updated: Sep 2017
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