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Drug Name: Desacetylvinblastine hydrazide conjugate with Folic acid and Mitomycin C View Structure
Description: A folate-targeted dual drug conjugate with antitumor activity; basically consists of subparts: folic acid; the hydrophilic peptide spacer, Asp-Asp-Asp-betaDpr-Cys; the Vinca alkaloid drug moiety, DAVLBH; the DNA alkylating drug moiety, N7-mercaptoethyl-mitomycin C (N7-me-MMC).

NCI: A folate receptor-targeting cytotoxic agent with potential antineoplastic activity. Folate receptor-targeted vinca alkaloid/mitomycin C. EC0225 contains two potent cytotoxic agents, a vinca alkaloid and mitomycin C, linked to a single folate molecule. ... see more at (NCI Thesaurus) 

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Last updated: Jun 2019