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Drug Name: Evofosfamide [USAN:INN] View Structure
Description: An hypoxia-activated prodrug of bromo-isophosphoramide mustard; an antineoplastic agent.

NCI: A hypoxia-activated prodrug consisting of a 2-nitroimidazole phosphoramidate conjugate with potential antineoplastic activity. The 2-nitroimidazole moiety of hypoxia-activated prodrug TH-302 acts as a hypoxic trigger, releasing the DNA-alkylating dibromo isophosphoramide mustard moiety within hypoxic regions of tumors. Normoxic tissues may be spared due to the hypoxia-specific activity of this agent, potentially reducing systemic toxicity. (NCI Thesaurus) 
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Last updated: Oct 2017
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