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Drug Name: Tozasertib lactate [USAN] View Structure
Description: A potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth.

NCI: The lactate salt of tozasertib, a synthetic, small-molecule Aurora kinase inhibitor with potential antitumor activity. Tozasertib binds to and inhibits Aurora kinases (AKs), thereby inducing apoptosis in tumor cells in which AKs are overexpressed. AKs, a family of serine-threonine kinases, are essential for mitotic progression, spindle formation, centrosome maturation, chromosomal segregation, and cytokinesis. (NCI Thesaurus)  



 
 
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Last updated: Dec 2017
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