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Drug Name: Vismodegib [USAN:INN] View Structure
Description: Inhibits the hedgehog pathway and ABC transporters; has antineoplastic activity.

NCI: An orally bioavailable small molecule with potential antineoplastic activity. Vismodegib targets the Hedgehog signaling pathway, blocking the activities of the Hedgehog-ligand cell surface receptors PTCH and/or SMO and suppressing Hedgehog signaling. The Hedgehog signaling pathway plays an important role in tissue growth and repair; aberrant constitutive activation of Hedgehog pathway signaling and uncontrolled cellular proliferation may be associated with mutations in the Hedgehog-ligand cell surface receptors PTCH and SMO. (NCI Thesaurus) 



 
 
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Last updated: Aug 2017
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