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Drug Name: Belinostat (Non-Stereospecific) View Structure
Description: A hydroxamate-type inhibitor of histone deacetylase.

The drug Belinostat is the E isomer at 866323-14-0

NCI: A novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. Belinostat targets HDAC enzymes, thereby inhibiting tumor cell proliferation, inducing apoptosis, promoting cellular differentiation, and inhibiting angiogenesis. This agent may sensitize drug-resistant tumor cells to other antineoplastic agents, possibly through a mechanism involving the down-regulation of thymidylate synthase. (NCI Thesaurus) 
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Last updated: Aug 2018
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