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Drug Name: Andecaliximab [USAN]
Description: Anti-matrix metalloproteinase-9 monoclonal antibody for treatment of ulcerative colitis.

NCI: anti-MMP-9 monoclonal antibody GS-5745 A humanized monoclonal antibody against matrix metalloproteinase 9 (MMP-9), with potential antineoplastic activity. Upon administration, anti-MMP-9 monoclonal antibody GS-5745 binds to MMP-9 and inhibits its enzymatic activity. This results in an inhibition of extracellular matrix protein degradation and, potentially, the inhibition of angiogenesis, tumor growth, invasion, and metastasis. MMP-9, a protein belonging to the MMP family, plays a key role in the degradation of collagens and proteoglycans; increased activity of MMP-9 has been associated with increased invasion and metastasis of cancer. (NCI Thesaurus) 

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Last updated: Feb 2020