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Drug Name: Sapanisertib [USAN:INN] View Structure
Description: An mTOR inhibitor.

NCI: TORC1/2 inhibitor MLN0128. An orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activity. TORC1/2 inhibitor MLN0128 binds to and inhibits both TORC1 and TORC2 complexes of mTOR, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation. TORC1 and 2 are upregulated in some tumors and play an important role in the PI3K/Akt/mTOR signaling pathway, which is frequently dysregulated in human cancers. (NCI Thesaurus) 



 
 
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Last updated: Dec 2017
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