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Drug Name: Pexidartinib [USAN] View Structure
Description: Inhibits both CSF1R and c-kit receptor tyrosine kinase.

NCI: Multitargeted tyrosine kinase inhibitor PLX3397A. Capsule formulation containing a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity. Multitargeted tyrosine kinase inhibitor PLX3397 binds to and inhibits phosphorylation of stem cell factor receptor (KIT), colony-stimulating factor-1 receptor (CSF1R) and FMS-like tyrosine kinase 3 (FLT3), which may result in the inhibition of tumor cell proliferation and down-modulation of macrophages, osteoclasts and mast cells involved in the osteolytic metastatic disease. FLT3, CSF1R and FLT3 are overexpressed or mutated in many cancer cell types and play major roles in tumor cell proliferation and metastasis. (NCI Thesaurus) 



 
 
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Last updated: Oct 2017
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