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1 result for Name/Synonym equals JEVTANA 
Drug Name: Cabazitaxel [USAN:INN] View Structure
Description: In multicenter phase II study for treatment of taxane-resistant metastatic breast cancer patients (2008).

NCI: An orally bioavailable semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel binds to and stabilizes tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, this agent is a poor substrate for the membrane-associated, multidrug resistance (MDR), P-glycoprotein (P-gp) efflux pump and may be useful for treating multidrug-resistant tumors. In addition, cabazitaxel penetrates the blood-brain barrier (BBB).(NCI Drug Dictionary) 

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Last updated: Oct 2016