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The Development of Buprenorphine as a Treatment For Opiate Dependence

Buprenorphine Hydrochloride and Buprenorphine with Naloxone are both effective drugs in overcoming heroin addiction. Both medications are formulations of the same active ingredient, Buprenorphine, and are used as detoxification agents for opiate addiction. Not only do these medications offer an alternative therapy for opiate dependence but also afford treatment in the private setting of a physician's office as opposed to a highly visible clinic.

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substance name MORPHINE HEROIN BUPRENORPHINE BUPRENORPHINE HCL
Compare PHYSICAL PROPERTIES and CHEMICAL STRUCTURES closely related Heroin morphine heroin buprenorphine buprenorphine hydrochloride
SIMILARITY TO HEROIN 88.9% 100% 75.7% 75%
MOL WEIGHT 285.341 369.4147 467.646 504.107
MOL FORMULA C17 H19 N O3 C21 H23 N O5 C29 H41 N O4 C29 H41 N O4 . Cl H
 
 
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Chronology of Events Snapshot

1970s Buprenorphine developed as an injectable medication for pain relief NIDA scientist recognizes potential of Buprenorphine for drug addiction treatment.

1978 Initial study to demonstrate effectiveness as treatment for opiate dependence.

1990 Siblingual solution developed for patient use.

Mid 1990s Tablet formulated using Buprenorphine with Naxolone to minimize potential for abuse.

NIDA funds clinical trial that establishes safety and effectiveness.

2000 Drug Abuse Treatment Act

2002 FDA Approval of Buprenorphine and Buprenorphine with Naloxone.

 

 

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