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Drug Name:  Carfilzomib [USAN:INN]    [show more names] [show structure]
Description:  An antineoplastic agent that inhibits the ubiquitin-proteasome pathway.

NCI: An epoxomicin derivate with potential antineoplastic activity. Carfilzomib irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S proteasome, an enzyme responsible for degrading a large variety of cellular proteins. Inhibition of proteasome-mediated proteolysis results in an accumulation of polyubiquinated proteins, which may lead to cell cycle arrest, induction of apoptosis, and inhibition of tumor growth.(NCI Thesaurus) 

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Last updated: Feb 2016